#!/bin/bash

VERSION="0.0.14 test"
afftype=".txt"
# trap keyboard interrupt (control-c)
trap control_c SIGINT

function setPath {
    cat <<SETPATH

--------------------------------------------------------------------------------------
Error locating ANTS
--------------------------------------------------------------------------------------
It seems that the ANTSPATH environment variable is not set. Please add the ANTSPATH
variable. This can be achieved by editing the .bash_profile in the home directory.
Add:

ANTSPATH=/home/yourname/bin/ants/

Or the correct location of the ANTS binaries.

Alternatively, edit this script ( `basename $0` ) to set up this parameter correctly.

SETPATH
    exit 1
}

# Uncomment the line below in case you have not set the ANTSPATH variable in your environment.
export ANTSPATH=${ANTSPATH:="/opt/ANTs/bin"} # EDIT THIS

ANTSPATH=/opt/ANTs/bin
if [  ${#ANTSPATH} -le 3 ]
    then
    setPath >&2
fi

if [ ! -s ${ANTSPATH}/ANTS ] ; then
  echo "ANTS program can't be found. Please (re)define \$ANTSPATH in your environment."
  exit
fi

# Test availability of helper scripts.
# No need to test this more than once. Can reside outside of the main loop.
ANTSSCRIPTNAME=${ANTSPATH}/antsIntroduction.sh
PEXEC=${ANTSPATH}/ANTSpexec.sh
SGE=${ANTSPATH}/waitForSGEQJobs.pl
PBS=${ANTSPATH}/waitForPBSQJobs.pl
XGRID=${ANTSPATH}/waitForXGridJobs.pl
SLURM=${ANTSPATH}/waitForSlurmJobs.pl

fle_error=0
for FLE in $ANTSSCRIPTNAME $PEXEC $SGE $XGRID $SLURM
  do
  if [ ! -x $FLE  ] ;
      then
      echo
      echo "--------------------------------------------------------------------------------------"
      echo " FILE $FLE DOES NOT EXIST -- OR -- IS NOT EXECUTABLE !!! $0 will terminate."
      echo "--------------------------------------------------------------------------------------"
      echo " if the file is not executable, please change its permissions. "
      fle_error=1
  fi
done
if [ $fle_error = 1 ] ; then
  exit 1
fi


#assuming .nii.gz as default file type. This is the case for ANTS 1.7 and up

function Usage {
    cat <<USAGE

Usage:

`basename $0` -d ImageDimension -o OUTPREFIX <other options> <images>

Compulsory arguments (minimal command line requires SGE cluster, otherwise use -c & -j options):

     -d:  ImageDimension: 2 or 3 (for 2 or 3 dimensional registration of single volume)
	  ImageDimension: 4 (for template generation of time-series data)

     -o:  OUTPREFIX; A prefix that is prepended to all output files.

<images>  List of images in the current directory, eg *_t1.nii.gz. Should be at the end
          of the command.

NB: All images to be added to the template should be in the same directory, and this script
should be invoked from that directory.

Optional arguments:

     -c:  Control for parallel computation (default 1) -- 0 == run serially,  1 == SGE qsub,
          2 == use PEXEC (localhost),  3 == Apple XGrid, 4 == PBS qsub, 5 == SLURM

     -q:  Set default queue for PBS jobs (default: nopreempt)

     -g:  Gradient step size (default 0.25) for template update. Does not affect the step size of individual registrations. The
          default of 0.25 should not be increased, smaller numbers result in more cautious template update steps.
          0.25 is an upper (aggressive) limit for this parameter.

     -i:  Iteration limit (default 4) -- iterations of the template construction (Iteration limit)*NumImages registrations.

     -j:  Number of cpu cores to use (default: 2; -- requires "-c 2")

     -m:  Max-iterations in each registration, eg 30x90x30

     -n:  N4BiasFieldCorrection of moving image (default 1) -- 0 == off, 1 == on. If 1, will run N4 before each registration. It is
          more efficient to run N4BiasFieldCorrection on the input images once, then build a template from the corrected images.

     -p:  Commands to prepend to job scripts (e.g., change into appropriate directory, set paths, etc)

     -r:  Do rigid-body registration of inputs before creating template (default 0) -- 0 == off 1 == on. Only useful when
          you do not have an initial template

     -s:  Type of similarity metric used for registration.

     -t:  Type of transformation model used for registration.

     -x:  XGrid arguments (e.g., -x "-p password -h controlhost")

     -z:  Use this this volume as the target of all inputs. When not used, the script
          will create an unbiased starting point by averaging all inputs. Use the full path!

	  If you do not have an initial template, it is advisible to run a few iterations with affine
          normalization only (-m 1x0x0) to get a sensible initial template, then pass this with -z
          to run full deformable registration.

Example:

`basename $0` -d 3 -m 30x50x20 -t GR -s CC -c 1 -o MY -z InitialTemplate.nii.gz  *RF*T1x.nii.gz

- In this example 30x50x20 iterations per registration are used for template creation (that is the default)
- Greedy-SyN and CC are the metrics to guide the mapping.
- Output is prepended with MY and the initial template is InitialTemplate.nii.gz (optional).
- The -c option is set to 1, which will result in using the Sun Grid Engine (SGE) to distribute the computation.
- if you do not have SGE, read the help for multi-core computation on the local machine, or Apple X-grid options.

--------------------------------------------------------------------------------------
ANTS was created by:
--------------------------------------------------------------------------------------
Brian B. Avants, Nick Tustison and Gang Song
Penn Image Computing And Science Laboratory
University of Pennsylvania

Please reference http://www.ncbi.nlm.nih.gov/pubmed/20851191 when employing this script
in your studies. A reproducible evaluation of ANTs similarity metric performance in
brain image registration:

* Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. Neuroimage, 2011.

Also see http://www.ncbi.nlm.nih.gov/pubmed/19818860 for more details.

The script has been updated and improved since this publication.

--------------------------------------------------------------------------------------
script adapted by N.M. van Strien, http://www.mri-tutorial.com | NTNU MR-Center
--------------------------------------------------------------------------------------
Apple XGrid support by Craig Stark
--------------------------------------------------------------------------------------

USAGE
    exit 1
}

function Help {
    cat <<HELP

`basename $0` will make a template out of the input files using an elastic
or diffeomorphic transformation. This script builds a template iteratively from the input
images and uses Sun Grid Engine (SGE) or multiple cpu cores on the localhost (min 2) to
parallelize the registration of each subject to the template.

Usage:

`basename $0` -d ImageDimension -o OUTPREFIX <other options> <images>

Example Case:

 bash `basename $0` -d 3 -m 30x50x20 -t GR  -s CC -c 1 -o MY -z InitialTemplate.nii.gz  *RF*T1x.nii.gz

 - In this case you use 30x50x20 iterations per registration
 - 4 iterations over template creation (that is the default)
 - With Greedy-SyN and CC metrics to guide the mapping.
 - Output is prepended with MY and the initial template is InitialTemplate.nii.gz (optional).
 - The -c option is set to 1 which will try to use SGE to distribute the computation.
 - If you do not have SGE, use -c 0 or -c 2 combined with -j.

 - Continue reading this help file if things are not yet clear.

Compulsory arguments (minimal command line requires SGE cluster, otherwise use -c & -j options)::

     -d:  ImageDimension: 2 or 3 (for 2 or 3 dimensional registration of single volume)
	  ImageDimension: 4 (for template generation of time-series data)

     -o:  OUTPREFIX; A prefix that is prepended to all output files.

<images>  List of images in the current directory, eg *_t1.nii.gz. Should be at the end
          of the command.

NB: All files to be added to the template should be in the same directory.

Optional arguments:

     -c:  Control for parallel computation (default 1) -- 0 == run serially,  1 == SGE qsub,
	  2 == use PEXEC (localhost), 3 == Apple XGrid, 4 == PBS Grid, 5 == SLURM

     -g:  Gradient step size; smaller in magnitude results in more cautious steps (default 0.25). This does not affect the step size
          of individual registrations; it lets you update the template more cautiously after each iteration by reducing the template
          update step size from 0.25 to a smaller positive number.

     -i:  Iteration limit (default = 4) for template construction. requires 4*NumImages registrations.

     -j:  Number of cpu cores to use (default: 2; --- set -c option to 2 to use this .

	  The optimal number of cpu cores to use for template generation depends on the availability of cores, the amount of
	  free working memory (RAM) and the resolution of the data. High resolution datasets typically require more RAM during
	  processing. Running out of RAM during a calculation will slow down all processing on your computer.

     -m:  Max-iterations

          Max-Iterations in form: JxKxL where
	     J = max iterations at coarsest resolution (here, reduce by power of 2^2)
	     K = middle resolution iterations (here,reduce by power of 2)
	     L = fine resolution iterations (here, full resolution) !!this level takes much
                 more time per iteration!!

	  Adding an extra value before JxKxL (i.e. resulting in IxJxKxL) would add another
	  iteration level.

     -n:  N4BiasFieldCorrection of moving image ( 0 = off; 1 = on (default) )

     -p:  Commands to prepend to job scripts (e.g., change into appropriate directory, set paths, etc)

     -r:  Do rigid-body registration of inputs before creating template (default 0) -- 0 == off 1 == on. Only useful when
          you do not have an initial template

          In case a template is specified (-z option), all inputs are registered to that template. If
          no template is specified, the inputs will be registered to the averaged input.


     -s:  Type of similarity metric used for registration.

	     For intramodal image registration, use:
	     CC = cross-correlation
	     MI = mutual information
	     PR = probability mapping (default)
	     MSQ = mean square difference (Demons-like)
	     SSD = sum of squared differences

	     For intermodal image registration, use:
	     MI = mutual information
	     PR = probability mapping (default)

     -t:  Type of transformation model used for registration.

	     For rigid image registration, use:
	     RI = Purely rigid
	     RA = Affine rigid

	     For elastic image registration, use:
	     EL = elastic transformation model (less deformation possible)

	     For diffeomorphic image registration, use:
	     SY = SyN with time (default) with arbitrary number of time points in time discretization
	     S2 = SyN with time optimized specifically for 2 time points in the time discretization
	     GR = Greedy SyN
	     EX = Exponential
             DD = Diffeomorphic Demons style exponential mapping

     -x:  XGrid arguments (e.g., -x "-p password -h controlhost")

     -z:  Use this this volume as the target of all inputs. When not used, the script
          will create an unbiased starting point by averaging all inputs. Use the full path!

          If you do not have an initial template, it is advisible to run a few iterations with affine
          normalization only (-m 1x0x0) to get a sensible initial template, then pass this with -z
          to run full deformable registration.


Requirements:

This scripts relies on the following scripts in your $ANTSPATH directory. The script
will terminate prematurely if these files are not present or are not executable.
- antsIntroduction.sh
- pexec.sh
- waitForSGEQJobs.pl (only for use with Sun Grid Engine)
- ANTSpexec.sh (only for use with localhost parallel execution)
- waitForXGridJobs.pl (only for use with Apple XGrid)
- waitForSlurmJobs.pl (only for use with SLURM)

--------------------------------------------------------------------------------------
Get the latest ANTS version at:
--------------------------------------------------------------------------------------
http://sourceforge.net/projects/advants/

--------------------------------------------------------------------------------------
Read the ANTS documentation at:
--------------------------------------------------------------------------------------
http://picsl.upenn.edu/ANTS/

--------------------------------------------------------------------------------------
ANTS was created by:
--------------------------------------------------------------------------------------
Brian B. Avants, Nick Tustison and Gang Song
Penn Image Computing And Science Laboratory
University of Pennsylvania

Please reference http://www.ncbi.nlm.nih.gov/pubmed/20851191 when employing this script
in your studies. A reproducible evaluation of ANTs similarity metric performance in
brain image registration:

* Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. Neuroimage, 2011.

Also see http://www.ncbi.nlm.nih.gov/pubmed/19818860 for more details.

The script has been updated and improved since this publication.

--------------------------------------------------------------------------------------
script adapted by N.M. van Strien, http://www.mri-tutorial.com | NTNU MR-Center
--------------------------------------------------------------------------------------
Apple XGrid support by Craig Stark
--------------------------------------------------------------------------------------

HELP
    exit 1
}

function reportMappingParameters {
    cat <<REPORTMAPPINGPARAMETERS

--------------------------------------------------------------------------------------
 Mapping parameters
--------------------------------------------------------------------------------------
 ANTSPATH is $ANTSPATH

 Dimensionality:			$DIM
 N4BiasFieldCorrection:			$N4CORRECT
 Similarity Metric:			$METRICTYPE
 Transformation:			$TRANSFORMATIONTYPE
 Regularization:			$REGULARIZATION
 MaxIterations:				$MAXITERATIONS
 Number Of MultiResolution Levels:	$NUMLEVELS
 OutputName prefix:			$OUTPUTNAME
 Template:  				$TEMPLATE
 Template Update Steps:			$ITERATIONLIMIT
 Template population:	   		$IMAGESETVARIABLE
--------------------------------------------------------------------------------------
REPORTMAPPINGPARAMETERS
}

function shapeupdatetotemplate {

    # local declaration of values
    dim=${DIM}
    template=${TEMPLATE}
    templatename=${TEMPLATENAME}
    outputname=${OUTPUTNAME}
    gradientstep=-${GRADIENTSTEP}

# debug only
# echo $dim
# echo ${template}
# echo ${templatename}
# echo ${outputname}
# echo ${outputname}*formed.nii*
# echo ${gradientstep}

# We find the average warp to the template and apply its inverse to the template image
# This keeps the template shape stable over multiple iterations of template building

    echo
    echo "--------------------------------------------------------------------------------------"
    echo " shapeupdatetotemplate 1"
    echo "--------------------------------------------------------------------------------------"
	${ANTSPATH}/AverageImages $dim ${template} 1 ${outputname}*formed.nii.gz

    echo
    echo "--------------------------------------------------------------------------------------"
    echo " shapeupdatetotemplate 2"
    echo "--------------------------------------------------------------------------------------"

	${ANTSPATH}/AverageImages $dim ${templatename}warp.nii.gz 0 `ls ${outputname}*Warp.nii.gz | grep -v "InverseWarp"`

    echo
    echo "--------------------------------------------------------------------------------------"
    echo " shapeupdatetotemplate 3"
    echo "--------------------------------------------------------------------------------------"

	${ANTSPATH}/MultiplyImages $dim ${templatename}warp.nii.gz ${gradientstep} ${templatename}warp.nii.gz


    echo
    echo "--------------------------------------------------------------------------------------"
    echo " shapeupdatetotemplate 4"
    echo "--------------------------------------------------------------------------------------"

	rm -f ${templatename}Affine${afftype}

    echo
    echo "--------------------------------------------------------------------------------------"
    echo " shapeupdatetotemplate 5"
    echo "--------------------------------------------------------------------------------------"

    # Averaging and inversion code --- both are 1st order estimates.
#    if [ ${dim} -eq 2   ] ; then
#      ANTSAverage2DAffine ${templatename}Affine${afftype} ${outputname}*Affine${afftype}
#    elif [ ${dim} -eq 3  ] ; then
#      ANTSAverage3DAffine ${templatename}Affine${afftype} ${outputname}*Affine${afftype}
#    fi

    ${ANTSPATH}/AverageAffineTransform ${dim} ${templatename}Affine${afftype} ${outputname}*Affine${afftype}
    ${ANTSPATH}/WarpImageMultiTransform ${dim} ${templatename}warp.nii.gz ${templatename}warp.nii.gz -i  ${templatename}Affine${afftype} -R ${template}
    ${ANTSPATH}/WarpImageMultiTransform ${dim} ${template} ${template} -i ${templatename}Affine${afftype} ${templatename}warp.nii.gz ${templatename}warp.nii.gz ${templatename}warp.nii.gz ${templatename}warp.nii.gz -R ${template}

    echo
    echo "--------------------------------------------------------------------------------------"
    echo " shapeupdatetotemplate 6"
    echo "--------------------------------------------------------------------------------------"
    echo
    ${ANTSPATH}/MeasureMinMaxMean ${dim} ${templatename}warp.nii.gz ${templatename}warplog.txt 1


}

function ANTSAverage2DAffine {

    OUTNM=${templatename}Affine${afftype}
    FLIST=${outputname}*Affine${afftype}
    NFILES=0
    PARAM1=0
    PARAM2=0
    PARAM3=0
    PARAM4=0
    PARAM5=0
    PARAM6=0
    PARAM7=0
    PARAM8=0
    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 2  `
    for x in $LL ; do  PARAM1=` awk -v a=$PARAM1 -v b=$x 'BEGIN{print (a + b)}' ` ;  let NFILES=$NFILES+1  ; done
    PARAM1=` awk -v a=$PARAM1 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 3  `
    for x in $LL ; do PARAM2=` awk -v a=$PARAM2 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM2=` awk -v a=$PARAM2 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 4  `
    for x in $LL ; do PARAM3=` awk -v a=$PARAM3 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM3=` awk -v a=$PARAM3 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 5  `
    for x in $LL ; do PARAM4=` awk -v a=$PARAM4 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM4=` awk -v a=$PARAM4 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 6  `
    for x in $LL ; do PARAM5=` awk -v a=$PARAM5 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM5=0 # ` awk -v a=$PARAM5 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 7  `
    for x in $LL ; do PARAM6=` awk -v a=$PARAM6 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM6=0 # ` awk -v a=$PARAM6 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` cat $FLIST | grep FixedParamet | cut -d ' ' -f 2  `
    for x in $LL ; do PARAM7=` awk -v a=$PARAM7 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM7=` awk -v a=$PARAM7 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` cat $FLIST | grep FixedParamet | cut -d ' ' -f 3  `
    for x in $LL ; do PARAM8=` awk -v a=$PARAM8 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM8=` awk -v a=$PARAM8 -v b=$NFILES 'BEGIN{print (a / b)}' `

    echo "# Insight Transform File V1.0 " > $OUTNM
    echo "# Transform 0 " >> $OUTNM
    echo "Transform: MatrixOffsetTransformBase_double_2_2  " >> $OUTNM
    echo "Parameters:  $PARAM1 $PARAM2 $PARAM3 $PARAM4 $PARAM5 $PARAM6  " >> $OUTNM
    echo "FixedParameters: $PARAM7 $PARAM8 " >> $OUTNM
}

function ANTSAverage3DAffine {

    OUTNM=${templatename}Affine${afftype}
    FLIST=${outputname}*Affine${afftype}
    NFILES=0
    PARAM1=0
    PARAM2=0
    PARAM3=0
    PARAM4=0
    PARAM5=0
    PARAM6=0
    PARAM7=0
    PARAM8=0
    PARAM9=0
    PARAM10=0
    PARAM11=0
    PARAM12=0
    PARAM13=0
    PARAM14=0
    PARAM15=0
    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 2  `
    for x in $LL ; do  PARAM1=` awk -v a=$PARAM1 -v b=$x 'BEGIN{print (a + b)}' ` ;  let NFILES=$NFILES+1  ; done
    PARAM1=` awk -v a=$PARAM1 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 3  `
    for x in $LL ; do PARAM2=` awk -v a=$PARAM2 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM2=` awk -v a=$PARAM2 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 4  `
    for x in $LL ; do PARAM3=` awk -v a=$PARAM3 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM3=` awk -v a=$PARAM3 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 5  `
    for x in $LL ; do PARAM4=` awk -v a=$PARAM4 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM4=` awk -v a=$PARAM4 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 6  `
    for x in $LL ; do PARAM5=` awk -v a=$PARAM5 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM5=` awk -v a=$PARAM5 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 7  `
    for x in $LL ; do PARAM6=` awk -v a=$PARAM6 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM6=` awk -v a=$PARAM6 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 8  `
    for x in $LL ; do PARAM7=` awk -v a=$PARAM7 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM7=` awk -v a=$PARAM7 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 9  `
    for x in $LL ; do PARAM8=` awk -v a=$PARAM8 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM8=` awk -v a=$PARAM8 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 10  `
    for x in $LL ; do PARAM9=` awk -v a=$PARAM9 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM9=` awk -v a=$PARAM9 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 11  `
    for x in $LL ; do PARAM10=` awk -v a=$PARAM10 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM10=0 # ` awk -v a=$PARAM10 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 12  `
    for x in $LL ; do PARAM11=` awk -v a=$PARAM11 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM11=0 # ` awk -v a=$PARAM11 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` head -n 4 $FLIST | grep Paramet | cut -d ' ' -f 13  `
    for x in $LL ; do PARAM12=` awk -v a=$PARAM12 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM12=0 # ` awk -v a=$PARAM12 -v b=$NFILES 'BEGIN{print (a / b)}' `

# origin params below

    LL=` cat $FLIST | grep FixedParamet | cut -d ' ' -f 2  `
    for x in $LL ; do  PARAM13=` awk -v a=$PARAM13 -v b=$x 'BEGIN{print (a + b)}' ` ;  done
    PARAM13=` awk -v a=$PARAM13 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` cat $FLIST | grep FixedParamet | cut -d ' ' -f 3  `
    for x in $LL ; do PARAM14=` awk -v a=$PARAM14 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM14=` awk -v a=$PARAM14 -v b=$NFILES 'BEGIN{print (a / b)}' `

    LL=` cat $FLIST | grep FixedParamet | cut -d ' ' -f 4  `
    for x in $LL ; do PARAM15=` awk -v a=$PARAM15 -v b=$x 'BEGIN{print (a + b)}' `  ; done
    PARAM15=` awk -v a=$PARAM15 -v b=$NFILES 'BEGIN{print (a / b)}' `

    echo "# Insight Transform File V1.0 " > $OUTNM
    echo "# Transform 0 " >> $OUTNM
    echo "Transform: MatrixOffsetTransformBase_double_3_3  " >> $OUTNM
    echo "Parameters:  $PARAM1 $PARAM2 $PARAM3 $PARAM4 $PARAM5 $PARAM6  $PARAM7 $PARAM8 $PARAM9 $PARAM10 $PARAM11 $PARAM12  " >> $OUTNM
    echo "FixedParameters: $PARAM13 $PARAM14 $PARAM15 " >> $OUTNM

}

function jobfnamepadding {

    files=`ls job*.sh`
    BASENAME1=`echo $files[1] | cut -d 'b' -f 1`

    for file in ${files}
      do

      if [ "${#file}" -eq "9" ]
	  then
	  BASENAME2=`echo $file | cut -d 'b' -f 2 `
	  mv "$file" "${BASENAME1}b_000${BASENAME2}"

      elif [ "${#file}" -eq "10" ]
	  then
	  BASENAME2=`echo $file | cut -d 'b' -f 2 `
	  mv "$file" "${BASENAME1}b_00${BASENAME2}"

      elif [ "${#file}" -eq "11" ]
	  then
	  BASENAME2=`echo $file | cut -d 'b' -f 2 `
	  mv "$file" "${BASENAME1}b_0${BASENAME2}"
      fi
    done

}


cleanup()
{
  echo "\n*** Performing cleanup, please wait ***\n"

  runningANTSpids=$( ps --ppid $$ -o pid= )

  for thePID in $runningANTSpids
  do
      echo "killing:  ${thePID}"
      kill ${thePID}
  done

  return $?
}

control_c()
# run if user hits control-c
{
  echo -en "\n*** User pressed CTRL + C ***\n"
  cleanup

  if [ $DOQSUB -eq 1 ] ; then
     qdel $jobIDs
  elif [ $DOQSUB -eq 5 ]; then
     scancel $jobIDs
  fi

  exit $?
  echo -en "\n*** Script cancelled by user ***\n"
}

#initializing variables with global scope
time_start=`date +%s`
currentdir=`pwd`
nargs=$#

MAXITERATIONS=30x90x20
LABELIMAGE=0 # initialize optional parameter
METRICTYPE=CC # initialize optional parameter
TRANSFORMATIONTYPE="GR" # initialize optional parameter
if [[ $dim == 4 ]] ; then
  # we use a more constrained regularization for 4D mapping b/c we expect deformations to be relatively small and local
  TRANSFORMATIONTYPE="GR_Constrained"
fi
N4CORRECT=1 # initialize optional parameter
DEFQUEUE=nopreempt
DOQSUB=1 # By default, buildtemplateparallel tries to do things in parallel
GRADIENTSTEP=0.25 # Gradient step size, smaller in magnitude means more smaller (more cautious) steps
ITERATIONLIMIT=4
CORES=2
TDIM=0
RIGID=0
RIGIDTYPE=" --do-rigid" # set to an empty string to use affine initialization
range=0
REGTEMPLATE=target
XGRIDOPTS=""
SCRIPTPREPEND=""
# System specific queue options, eg "-q name" to submit to a specific queue
# It can be set to an empty string if you do not need any special cluster options
QSUBOPTS="" # EDIT THIS
OUTPUTNAME=antsBTP

##Getting system info from linux can be done with these variables.
# RAM=`cat /proc/meminfo | sed -n -e '/MemTotal/p' | awk '{ printf "%s %s\n", $2, $3 ; }' | cut -d " " -f 1`
# RAMfree=`cat /proc/meminfo | sed -n -e '/MemFree/p' | awk '{ printf "%s %s\n", $2, $3 ; }' | cut -d " " -f 1`
# cpu_free_ram=$((${RAMfree}/${cpu_count}))

if [ ${OSTYPE:0:6} == 'darwin' ]
	then
	cpu_count=`sysctl -n hw.physicalcpu`
else
	cpu_count=`cat /proc/cpuinfo | grep processor | wc -l`
fi

# Provide output for Help
if [ "$1" == "-h" ]
    then
    Help >&2

fi

# reading command line arguments
while getopts "c:q:d:g:i:j:h:m:n:o:p:s:r:t:x:z:" OPT
  do
  case $OPT in
      h) #help
	  echo "$USAGE"
	  exit 0
	  ;;
      c) #use SGE cluster
	  DOQSUB=$OPTARG
	  if [[ ${#DOQSUB} -gt 2 ]] ; then
	      echo " DOQSUB must be an integer value (0=serial, 1=SGE qsub, 2=try pexec, 3=XGrid, 4=PBS qsub, 5=SLURM) you passed  -c $DOQSUB "
	      exit 1
	  fi
	  ;;
      q) #override default qsub queue
	  DEFQUEUE=$OPTARG
	  ;;
      d) #dimensions
	  DIM=$OPTARG
	  if [[ ${DIM} -eq 4 ]] ; then
	      DIM=3
	      TDIM=4
	  fi
	  ;;
      g) #gradient stepsize (default = 0.25)
	  GRADIENTSTEP=$OPTARG
	  ;;
      i) #iteration limit (default = 3)
	  ITERATIONLIMIT=$OPTARG
	  ;;
      j) #number of cpu cores to use (default = 2)
	  CORES=$OPTARG
	  ;;
      m) #max iterations other than default
	  MAXITERATIONS=$OPTARG
	  ;;
      n) #apply bias field correction
	  N4CORRECT=$OPTARG
	  ;;
      o) #output name prefix
	  OUTPUTNAME=$OPTARG
	  TEMPLATENAME=${OUTPUTNAME}template
	  TEMPLATE=${TEMPLATENAME}.nii.gz
	  ;;
      p) #Script prepend
	  SCRIPTPREPEND=$OPTARG
	  ;;
      s) #similarity model
	  METRICTYPE=$OPTARG
	  ;;
      r) #start with rigid-body registration
	  RIGID=$OPTARG
	  ;;
      t) #transformation model
	  TRANSFORMATIONTYPE=$OPTARG
	  ;;
      x) #initialization template
	  XGRIDOPTS=$XGRIDOPTS
	  ;;
      z) #initialization template
	  REGTEMPLATE=$OPTARG
	  ;;
      \?) # getopts issues an error message
      echo "$USAGE" >&2
      exit 1
      ;;
  esac
done

# Provide different output for Usage and Help
if [ ${TDIM} -eq 4 ] && [ $nargs -lt 5 ]
    then
    Usage >&2
elif [ ${TDIM} -eq 4 ] && [ $nargs -eq 5 ]
    then
    echo ""
    # This option is required to run 4D template creation on SGE with a minimal command line
elif [ $nargs -lt 6 ]
    then
    Usage >&2
fi

if [[ $DOQSUB -eq 1 || $DOQSUB -eq 4 ]] ; then
  qq=`which  qsub`
  if [  ${#qq} -lt 1 ] ; then
    echo do you have qsub?  if not, then choose another c option ... if so, then check where the qsub alias points ...
    exit
  fi
fi
if [[ $DOQSUB -eq 5 ]]; then
  qq=`which sbatch`
  if [[ ${#qq} -lt 1 ]]; then
    echo "do you have sbatch?  if not, then choose another c option ... if so, then check where the sbatch alias points ..."
    exit
  fi
fi

# Creating the file list of images to make a template from.
# Shiftsize is calculated because a variable amount of arguments can be used on the command line.
# The shiftsize variable will give the correct number of arguments to skip. Issuing shift $shiftsize will
# result in skipping that number of arguments on the command line, so that only the input images remain.
shiftsize=$(($OPTIND - 1))
shift $shiftsize
# The invocation of $* will now read all remaining arguments into the variable IMAGESETVARIABLE
IMAGESETVARIABLE=$*
NINFILES=$(($nargs - $shiftsize))

# FSL not needed anymore, all dependent on ImageMath
# #test if FSL is available in case of 4D, exit if not
# if [  ${TDIM} -eq 4 ] && [  ${#FSLDIR} -le 0 ]
#     then
#     setFSLPath >&2
# fi

if [ ${NINFILES} -eq 0 ]
    then
    echo "Please provide at least 2 filenames for the template."
    echo "Use `basename $0` -h for help"
    exit 1
elif [[ ${NINFILES} -eq 1 ]]
    then

    range=`${ANTSPATH}/ImageMath $TDIM abs nvols ${IMAGESETVARIABLE} | tail -1 | cut -d "," -f 4 | cut -d " " -f 2 | cut -d "]" -f 1 `

    if [ ${range} -eq 1 ] && [ ${TDIM} -ne 4 ]
	then
	echo "Please provide at least 2 filenames for the template."
	echo "Use `basename $0` -h for help"
	exit 1
    elif [ ${range} -gt 1 ] && [ ${TDIM} -ne 4 ]
	then
	echo "This is a multivolume file. Use -d 4"
	echo "Use `basename $0` -h for help"
	exit 1
    elif [ ${range} -gt 1 ] && [ ${TDIM} -eq 4 ]
	then
	echo
	echo "--------------------------------------------------------------------------------------"
	echo " Creating template of 4D input. "
	echo "--------------------------------------------------------------------------------------"

	#splitting volume
	#setting up working dirs
	tmpdir=${currentdir}/tmp_${RANDOM}_${RANDOM}_${RANDOM}_$$
	(umask 077 && mkdir ${tmpdir}) || {
		echo "Could not create temporary directory! Exiting." 1>&2
		exit 1
	}

	mkdir ${tmpdir}/selection

	#split the 4D file into 3D elements
	cp ${IMAGESETVARIABLE} ${tmpdir}/
	cd ${tmpdir}/
 #       ${ANTSPATH}/ImageMath $TDIM vol0.nii.gz TimeSeriesSubset ${IMAGESETVARIABLE} ${range}
#	rm -f ${IMAGESETVARIABLE}

	# selecting 16 volumes randomly from the timeseries for averaging, placing them in tmp/selection folder.
	# the script will automatically divide timeseries into $total_volumes/16 bins from wich to take the random volumes;
        # if there are more than 32 volumes in the time-series (in case they are smaller
	nfmribins=2
	let
	if [ ${range} -gt 31  ]  ; then
		BINSIZE=$((${range} / ${nfmribins}))
		j=1 # initialize counter j
		for ((i = 0; i < ${nfmribins} ; i++))
			do

			FLOOR=$((${i} * ${BINSIZE}))
			BINrange=$((${j} * ${BINSIZE}))

			# Retrieve random number between two limits.
			number=0   #initialize
				while [ "$number" -le $FLOOR ]
				do
				number=$RANDOM
					if [ $i -lt 15 ]
						then
						let "number %= $BINrange"  # Scales $number down within $range.
					elif [ $i -eq 15 ]
						then
						let "number %= $range"  # Scales $number down within $range.
					fi
				done

	#debug only
			echo
			echo "Random number between $FLOOR and $BINrange ---  $number"
#			echo "Random number between $FLOOR and $range ---  $number"
				if [ ${number} -lt 10 ]
					then
					${ANTSPATH}/ImageMath $TDIM selection/vol000${number}.nii.gz ExtractSlice ${IMAGESETVARIABLE} ${number}
#					cp vol000${number}.nii.gz selection/
				elif [ ${number} -ge 10 ] && [ ${number} -lt 100 ]
					then
					${ANTSPATH}/ImageMath $TDIM selection/vol00${number}.nii.gz ExtractSlice ${IMAGESETVARIABLE} ${number}
#					cp vol00${number}.nii.gz selection/
				elif [ ${number} -ge 100 ] && [ ${number} -lt 1000 ]
					then
					${ANTSPATH}/ImageMath $TDIM selection/vol0${number}.nii.gz ExtractSlice ${IMAGESETVARIABLE} ${number}
#					cp vol0${number}.nii.gz selection/
				fi

			let j++
		done

	elif [ ${range} -gt ${nfmribins}  ] && [ ${range} -lt 32  ]
		then

			for ((i = 0; i < ${nfmribins} ; i++))
			do
			number=$RANDOM
			let "number %= $range"

				if [ ${number} -lt 10 ]
					then
					${ANTSPATH}/ImageMath $TDIM selection/vol0.nii.gz ExtractSlice ${IMAGESETVARIABLE} ${number}
#					cp vol000${number}.nii.gz selection/
				elif [ ${number} -ge 10 ] && [ ${number} -lt 100 ]
					then
					${ANTSPATH}/ImageMath $TDIM selection/vol0.nii.gz ExtractSlice ${IMAGESETVARIABLE} ${number}
#					cp vol00${number}.nii.gz selection/
				fi
			done

	elif [ ${range} -le ${nfmribins}  ]
		then

		${ANTSPATH}/ImageMath selection/$TDIM vol0.nii.gz TimeSeriesSubset ${IMAGESETVARIABLE} ${range}
#		cp *.nii.gz selection/

	fi

	# set filelist variable
	rm -f ${IMAGESETVARIABLE}
	cd selection/
	IMAGESETVARIABLE=`ls *.nii.gz`

    fi
fi

# exit
# check for an initial template image and perform rigid body registration if requested
if [ ! -s $REGTEMPLATE ]
    then
    echo
    echo "--------------------------------------------------------------------------------------"
    echo " No initial template exists. Creating a population average image from the inputs."
    echo "--------------------------------------------------------------------------------------"
    ${ANTSPATH}/AverageImages $DIM $TEMPLATE 1 $IMAGESETVARIABLE
else
    echo
    echo "--------------------------------------------------------------------------------------"
    echo " Initial template found.  This will be used for guiding the registration. use : $REGTEMPLATE and $TEMPLATE "
    echo "--------------------------------------------------------------------------------------"
	# now move the initial registration template to OUTPUTNAME, otherwise this input gets overwritten.

    cp ${REGTEMPLATE} ${TEMPLATE}

fi


if [ ! -s $TEMPLATE ] ; then
  echo Your template : $TEMPLATE was not created.  This indicates trouble!  You may want to check correctness of your input parameters. exiting.
  exit
fi
# remove old job bash scripts
rm -f job*.sh

if [ "$RIGID" -eq 1 ] ;
    then
    count=0
    jobIDs=""

    RIGID_IMAGESET=""

    for IMG in $IMAGESETVARIABLE
      do

      RIGID_IMAGESET="$RIGID_IMAGESET rigid_${IMG}"

      BASENAME=` echo ${IMG} | cut -d '.' -f 1 `

      exe=" ${ANTSPATH}/ANTS $DIM -m MI[${TEMPLATE},${IMG},1,32] -o rigid_${IMG} -i 0 --use-Histogram-Matching --number-of-affine-iterations 10000x10000x10000x10000x10000 $RIGIDTYPE"
      exe2="${ANTSPATH}/WarpImageMultiTransform $DIM ${IMG} rigid_${IMG} rigid_${BASENAME}Affine${afftype} -R ${TEMPLATE}"
      pexe=" $exe >> job_${count}_metriclog.txt "

      qscript="job_${count}_qsub.sh"
      rm -f $qscript

      if [[ $DOQSUB -eq 5 ]]; then
         # SLURM job scripts must start with a shebang
         echo '#!/bin/sh' > $qscript
      fi

      echo "$SCRIPTPREPEND" >> $qscript

      echo "$exe" >> $qscript

      echo "$exe2" >> $qscript

      if [ $DOQSUB -eq 1 ] ; then
		id=`qsub -cwd -S /bin/bash -N antsBuildTemplate_rigid -v ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS=1,LD_LIBRARY_PATH=$LD_LIBRARY_PATH,ANTSPATH=$ANTSPATH $QSUBOPTS $qscript | awk '{print $3}'`
		jobIDs="$jobIDs $id"
		    sleep 0.5
      elif [ $DOQSUB -eq 4 ]; then
        echo "cp -R /jobtmp/pbstmp.\$PBS_JOBID/* ${currentdir}" >> $qscript;
		id=`qsub -N antsrigid -v ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS=1,LD_LIBRARY_PATH=$LD_LIBRARY_PATH,ANTSPATH=$ANTSPATH $QSUBOPTS -q $DEFQUEUE -l nodes=1:ppn=1 -l walltime=4:00:00 $qscript | awk '{print $1}'`
		jobIDs="$jobIDs $id"
        sleep 0.5
      elif  [ $DOQSUB -eq 2 ] ; then
        # Send pexe and exe2 to same job file so that they execute in series
        echo $pexe >> job${count}_r.sh
        echo $exe2 >> job${count}_r.sh
      elif  [ $DOQSUB -eq 3 ] ; then
        id=`xgrid $XGRIDOPTS -job submit /bin/bash $qscript | awk '{sub(/;/,"");print $3}' | tr '\n' ' ' | sed 's:  *: :g'`
        #echo "xgrid $XGRIDOPTS -job submit /bin/bash $qscript"
        jobIDs="$jobIDs $id"
      elif [[ $DOQSUB -eq 5 ]]; then
        id=`sbatch --job-name=antsrigid --export=ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS=1,LD_LIBRARY_PATH=$LD_LIBRARY_PATH,ANTSPATH=$ANTSPATH $QSUBOPTS --nodes=1 --cpus-per-task=1 --time=4:00:00 $qscript | rev | cut -f1 -d\ | rev`
        jobIDs="$jobIDs $id"
        sleep 0.5
      elif  [ $DOQSUB -eq 0 ] ; then
        # execute jobs in series
        $exe
        $exe2
      fi

      ((count++))
    done


    if [ $DOQSUB -eq 1 ];
	then
	# Run jobs on SGE and wait to finish
	echo
	echo "--------------------------------------------------------------------------------------"
	echo " Starting ANTS rigid registration on SGE cluster. Submitted $count jobs "
	echo "--------------------------------------------------------------------------------------"
        # now wait for the jobs to finish. Rigid registration is quick, so poll queue every 60 seconds
	${ANTSPATH}/waitForSGEQJobs.pl 1 60 $jobIDs

	# Returns 1 if there are errors
	if [ ! $? -eq 0 ]; then
	    echo "qsub submission failed - jobs went into error state"
	    exit 1;
	fi
    fi

    if [ $DOQSUB -eq 4 ];
	then
	# Run jobs on PBS and wait to finish
	echo
	echo "--------------------------------------------------------------------------------------"
	echo " Starting ANTS rigid registration on PBS cluster. Submitted $count jobs "
	echo "--------------------------------------------------------------------------------------"
        # now wait for the jobs to finish. Rigid registration is quick, so poll queue every 60 seconds
	${ANTSPATH}/waitForPBSQJobs.pl 1 60 $jobIDs

	# Returns 1 if there are errors
	if [ ! $? -eq 0 ]; then
	    echo "qsub submission failed - jobs went into error state"
	    exit 1;
	fi
    fi

    # Run jobs on localhost and wait to finish
    if [ $DOQSUB -eq 2 ];
	then
	echo
	echo "--------------------------------------------------------------------------------------"
	echo " Starting ANTS rigid registration on max ${CORES} cpucores. "
	echo " Progress can be viewed in job*_metriclog.txt"
	echo "--------------------------------------------------------------------------------------"
	jobfnamepadding #adds leading zeros to the jobnames, so they are carried out chronologically
	chmod +x job*.sh
	$PEXEC -j ${CORES} "sh" job*.sh
    fi

    if [ $DOQSUB -eq 3 ];
	then
	# Run jobs on XGrid and wait to finish
	echo
	echo "--------------------------------------------------------------------------------------"
	echo " Starting ANTS rigid registration on XGrid cluster. Submitted $count jobs "
	echo "--------------------------------------------------------------------------------------"
        # now wait for the jobs to finish. Rigid registration is quick, so poll queue every 60 seconds
	${ANTSPATH}/waitForXGridJobs.pl -xgridflags "$XGRIDOPTS" -verbose -delay 30 $jobIDs
	# Returns 1 if there are errors
	if [ ! $? -eq 0 ]; then
	    echo "XGrid submission failed - jobs went into error state"
	    exit 1;
	fi
    fi

    if [ $DOQSUB -eq 5 ];
	then
	# Run jobs on SLURM and wait to finish
	echo
	echo "--------------------------------------------------------------------------------------"
	echo " Starting ANTS rigid registration on SLURM cluster. Submitted $count jobs "
	echo "--------------------------------------------------------------------------------------"
        # now wait for the jobs to finish. Rigid registration is quick, so poll queue every 60 seconds
	${ANTSPATH}/waitForSlurmJobs.pl 1 60 $jobIDs

	# Returns 1 if there are errors
	if [ ! $? -eq 0 ]; then
	    echo "SLURM submission failed - jobs went into error state"
	    exit 1;
	fi
    fi


    # Update template
    ${ANTSPATH}/AverageImages $DIM $TEMPLATE 1 $RIGID_IMAGESET

    # cleanup and save output in seperate folder

    mkdir rigid
    mv *.cfg rigid*.nii.gz *Affine${afftype} rigid/

    # backup logs
    if [ $DOQSUB -eq 1 ];
	then
	mv antsBuildTemplate_rigid* rigid/

        # Remove qsub scripts
	rm -f job_${count}_qsub.sh
    elif [ $DOQSUB -eq 4 ];
      then
      mv antsrigid* rigid/

        # Remove qsub scripts
	rm -f job_${count}_qsub.sh

    elif [ $DOQSUB -eq 2 ];
		then
		mv job*.txt rigid/
	elif [ $DOQSUB -eq 3 ];
		then
		rm -f job_*_qsub.sh
    elif [[ $DOQSUB -eq 5 ]];
        then
        mv slurm-*.out rigid/
        mv job*.txt rigid/

        # Remove qsub scripts
        rm -f ${outdir}/job_${count}_qsub.sh
    fi


fi # endif RIGID



# Begin Main Loop
ITERATLEVEL=(` echo $MAXITERATIONS | tr 'x' ' ' `)
NUMLEVELS=${#ITERATLEVEL[@]}

# debugging only
#echo $ITERATLEVEL
#echo $NUMLEVELS
#echo ${ITERATIONLIMIT}

echo
echo "--------------------------------------------------------------------------------------"
echo " Start to build template: ${TEMPLATE}"
echo "--------------------------------------------------------------------------------------"
reportMappingParameters

i=0
while [  $i -lt ${ITERATIONLIMIT} ]
  do

  itdisplay=$((i+1))

  rm -f  ${OUTPUTNAME}*Warp*.nii*
  rm -f job*.sh

# Used to save time by only running coarse registration for the first couple of iterations
# But with decent initialization, this is probably not worthwhile.
# If you uncomment this, replace MAXITERATIONS with ITERATIONS in the call to ants below
#
# # For the first couple of iterations, use high-level registration only
# # eg if MAXITERATIONS=30x90x20, then for iteration 0, do 30x0x0
# # for iteration 1 do 30x90x0, then do 30x90x20 on subsequent iterations
# if [ $i -gt $((NUMLEVELS - 1)) ]
#    then
#    ITERATIONS=$MAXITERATIONS
# else
#
#    ITERATIONS=${ITERATLEVEL[0]}
#
#    for (( n = 1 ; n < ${NUMLEVELS}; n++ ))
#      do
#      ITERATIONS=${ITERATIONS}x$((${ITERATLEVEL[n]} * $((n <= i)) ))
#    done
# fi

  # Job IDs of jobs submitted to queue in loop below
  jobIDs=""

  # Reinitialize count to 0
  count=0

  # Submit registration of each input to volume template to SGE or run locally.
  for IMG in $IMAGESETVARIABLE
    do
    # 1 determine working dir
    dir=`pwd`

    # 2 determine new filename
    POO=${OUTPUTNAME}${IMG}


    # 3 Make variable OUTFILENAME and remove anything behind . ; for example .nii.gz.gz
    OUTFN=${POO%.*.*}

    # 4 Test if outputfilename has only a single extention and remove that
    if [ ${#OUTFN} -eq ${#POO} ]
	then
	OUTFN=${OUTPUTNAME}${IMG%.*}
    fi

    # 5 prepare registration command
    exe="${ANTSSCRIPTNAME} -d ${DIM} -r ${dir}/${TEMPLATE} -i ${dir}/${IMG} -o ${dir}/${OUTFN} -m ${MAXITERATIONS} -n ${N4CORRECT} -s ${METRICTYPE} -t ${TRANSFORMATIONTYPE} -f 1 "
    pexe=" $exe >> job_${count}_${i}_metriclog.txt "

    # 6 submit to SGE (DOQSUB=1), PBS (DOQSUB=4), PEXEC (DOQSUB=2), XGrid (DOQSUB=3) or else run locally (DOQSUB=0)
    if [ $DOQSUB -eq 1 ]; then
      id=`qsub -cwd -N antsBuildTemplate_deformable_${i} -S /bin/bash -v ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS=1,LD_LIBRARY_PATH=$LD_LIBRARY_PATH,ANTSPATH=$ANTSPATH $QSUBOPTS $exe | awk '{print $3}'`
      jobIDs="$jobIDs $id"
      sleep 0.5
    elif [ $DOQSUB -eq 4 ]; then
      qscript="job_${count}_${i}.sh"
      echo "$SCRIPTPREPEND" > $qscript
      echo "$exe" >> $qscript
      echo "cp -R /jobtmp/pbstmp.\$PBS_JOBID/* ${currentdir}" >> $qscript;
      id=`qsub -N antsdef${i} -v ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS=1,LD_LIBRARY_PATH=$LD_LIBRARY_PATH,ANTSPATH=$ANTSPATH -q $DEFQUEUE -l nodes=1:ppn=1 -l walltime=4:00:00 $QSUBOPTS $qscript | awk '{print $1}'`
      jobIDs="$jobIDs $id"
      sleep 0.5
    elif [ $DOQSUB -eq 2 ] ; then
      echo $pexe
      echo $pexe >> job${count}_${i}.sh
    elif [ $DOQSUB -eq 3 ] ; then
      qscript="job_${count}_${i}.sh"
      #exe="${ANTSSCRIPTNAME} -d ${DIM} -r ./${TEMPLATE} -i ./${IMG} -o ./${OUTFN} -m ${MAXITERATIONS} -n ${N4CORRECT} -s ${METRICTYPE} -t ${TRANSFORMATIONTYPE} "
      echo "$SCRIPTPREPEND" > $qscript
      echo "$exe" >> $qscript
      id=`xgrid $XGRIDOPTS -job submit /bin/bash $qscript | awk '{sub(/;/,"");print $3}' | tr '\n' ' ' | sed 's:  *: :g'`
      jobIDs="$jobIDs $id"
      qscript="job_${count}_${i}.sh"
    elif [[ $DOQSUB -eq 5 ]] ; then
      qscript="job_${count}_${i}.sh"
      echo '#!/bin/sh' > $qscript
      echo -e "$SCRIPTPREPEND" >> $qscript
      echo -e "$exe" >> $qscript
      id=`sbatch --mem-per-cpu=32768M --job-name=antsdef${i} --export=ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS=1,LD_LIBRARY_PATH=$LD_LIBRARY_PATH,ANTSPATH=$ANTSPATH --nodes=1 --cpus-per-task=1 --time=4:00:00 $QSUBOPTS $qscript | rev | cut -f1 -d\ | rev`
      jobIDs="$jobIDs $id"
      sleep 0.5
    elif  [ $DOQSUB -eq 0 ] ; then
      bash $exe
    fi

    # counter updated, but not directly used in this loop
    count=`expr $count + 1`;

#		echo " submitting job number $count " # for debugging only
  done

  # SGE wait for script to finish
  if [ $DOQSUB -eq 1 ];
      then
      echo
      echo "--------------------------------------------------------------------------------------"
      echo " Starting ANTS registration on SGE cluster. Iteration: $itdisplay of $ITERATIONLIMIT"
      echo "--------------------------------------------------------------------------------------"

      # now wait for the stuff to finish - this will take a while so poll queue every 10 mins
      ${ANTSPATH}/waitForSGEQJobs.pl 1 600 $jobIDs

      if [ ! $? -eq 0 ]; then
        echo "qsub submission failed - jobs went into error state"
        exit 1;
      fi

  elif [ $DOQSUB -eq 4 ];

      then
      echo
      echo "--------------------------------------------------------------------------------------"
      echo " Starting ANTS registration on PBS cluster. Iteration: $itdisplay of $ITERATIONLIMIT"
      echo "--------------------------------------------------------------------------------------"

      # now wait for the stuff to finish - this will take a while so poll queue every 10 mins
      ${ANTSPATH}/waitForPBSQJobs.pl 1 600 $jobIDs

      if [ ! $? -eq 0 ]; then
        echo "qsub submission failed - jobs went into error state"
        exit 1;
      fi

  fi


  # Run jobs on localhost and wait to finish
  if [ $DOQSUB -eq 2 ];
      then
      echo
      echo "--------------------------------------------------------------------------------------"
      echo " Starting ANTS registration on max ${CORES} cpucores. Iteration: $itdisplay of $ITERATIONLIMIT"
      echo " Progress can be viewed in job*_${i}_metriclog.txt"
      echo "--------------------------------------------------------------------------------------"
      jobfnamepadding #adds leading zeros to the jobnames, so they are carried out chronologically
      chmod +x job*.sh
      $PEXEC -j ${CORES} sh job*.sh
  fi

  if [ $DOQSUB -eq 3 ];
    then
    # Run jobs on XGrid and wait to finish
    echo
    echo "--------------------------------------------------------------------------------------"
    echo " Starting ANTS registration on XGrid cluster. Submitted $count jobs "
    echo "--------------------------------------------------------------------------------------"
           # now wait for the jobs to finish. This is slow, so poll less often
    ${ANTSPATH}/waitForXGridJobs.pl -xgridflags "$XGRIDOPTS" -verbose -delay 300 $jobIDs
    # Returns 1 if there are errors
    if [ ! $? -eq 0 ]; then
        echo "XGrid submission failed - jobs went into error state"
        exit 1;
    fi
  fi

  if [[ $DOQSUB -eq 5 ]];
    then
    # Run jobs on SLURM and wait to finish
    echo
    echo "--------------------------------------------------------------------------------------"
    echo " Starting ANTS registration on SLURM cluster. Submitted $count jobs "
    echo "--------------------------------------------------------------------------------------"

    # now wait for the stuff to finish - this will take a while so poll queue every 10 mins
    ${ANTSPATH}/waitForSlurmJobs.pl 1 600 $jobIDs

    if [[ ! $? -eq 0 ]];
        then
        echo "SLURM submission failed - jobs went into error state"
        exit 1;
    fi
  fi

  shapeupdatetotemplate ${DIM} ${TEMPLATE} ${TEMPLATENAME} ${OUTPUTNAME} ${GRADIENTSTEP}

  echo
  echo "--------------------------------------------------------------------------------------"
  echo " Backing up results from iteration $itdisplay"
  echo "--------------------------------------------------------------------------------------"

  mkdir ${TRANSFORMATIONTYPE}_iteration_${i}
  cp ${TEMPLATENAME}warp*log.txt *.cfg *${OUTPUTNAME}*.nii.gz ${TRANSFORMATIONTYPE}_iteration_${i}/

  # backup logs
  if [ $DOQSUB -eq 1 ];
      then
      mv antsBuildTemplate_deformable_* ${TRANSFORMATIONTYPE}_iteration_${i}

  elif [ $DOQSUB -eq 4 ];
      then
      mv antsdef* ${TRANSFORMATIONTYPE}_iteration_${i}

  elif [ $DOQSUB -eq 2 ];
      then
      mv job*.txt ${TRANSFORMATIONTYPE}_iteration_${i}
  elif [ $DOQSUB -eq 3 ];
      then
      rm -f job_*.sh
  elif [[ $DOQSUB -eq 5 ]];
      then
      mv slurm-*.out ${TRANSFORMATIONTYPE}_iteration_${i}
      mv job*.txt ${TRANSFORMATIONTYPE}_iteration_${i}
  fi

  ((i++))

done

# end main loop

rm -f job*.sh

#cleanup of 4D files
if [ "${range}" -gt 1 ] && [ "${TDIM}" -eq 4 ]
    then
    mv ${tmpdir}/selection/${TEMPLATE} ${currentdir}/
    cd ${currentdir}
    rm -rf ${tmpdir}/
fi

time_end=`date +%s`
time_elapsed=$((time_end - time_start))

echo
echo "--------------------------------------------------------------------------------------"
echo " Done creating: ${TEMPLATE}"
echo " Script executed in $time_elapsed seconds"
echo " $(( time_elapsed / 3600 ))h $(( time_elapsed %3600 / 60 ))m $(( time_elapsed % 60 ))s"
echo "--------------------------------------------------------------------------------------"

exit 0
